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The postdoctoral fellow will work on developing new technologies aimed at turning the gastrointestinal GI immune system of a mouse into a technology called Intestinal Selection of Immunogenic Antigens ISIA that can distinguish highly immunogenic antigens from less immunogenic antigens and will apply the new technology to vaccinology. The technology employs a combination of synthetic biology, new insights into the microbiome, the notion of DNA barcoding, and Gram-negative autotransporters to interrogate, without any advance assumptions or biases, the entire, intact GI immune system of a mouse.